CXCL10 Is Associated with Increased Cerebrospinal Fluid Immune Cell Infiltration and Disease Duration in Multiple Sclerosis

Background: Cerebrospinal fluid (CSF) is an important sampling site for putative biomarkers and contains immune cells. CXCL10 a multiple sclerosis (MS)-relevant chemokine that present in the injured central nervous system recruits CXCR3+ cells toward tissues. Objective: Perform comprehensive evaluation to determine potential relationship between various cell subsets CNS of MS control cases. Methods: In cases, was measured CSF plasma by ELISA. Immune within both peripheral blood were quantified flow cytometry. Results: Compared non-inflammatory neurological disease (NIND) cases had significantly higher (p = 0.021); also correlated with total numbers 0.04) T infiltrates (CD3+, p 0.01; CD4+, CD8+, 0.02); expression CXCR3 on not associated CXCL10. Conclusions: Elevated levels are increased but appear be independent expression. These results support importance elevated suggest presence alternative mechanism outside solely influencing trafficking.